It’s 1954, and on an isolated island off the coast of Boston lies the notorious Ashecliffe psychiatric hospital. Housing some of the century’s most dangerous criminals, it is normally completely off-limits to outsiders but, when one of the patients mysteriously vanishes, Detective Teddy Daniels (Leonardo DiCaprio) and his new partner Chuck Aule (Mark Ruffalo) arrive to solve the disappearance. Coming up against a secretive and tight-lipped staff, headed by Dr Cawley (Ben Kingsley), Teddy finds his investigation hampered at every turn. When he finally discovers what’s been happening in the heavily-guarded lighthouse, Teddy thinks he’s well on the way to cracking the case. But, as he begins having powerful dreams about his time spent liberating German concentration camps during WWII, and vivid hallucinations of his dead wife (Michelle Williams), can Teddy leave Shutter Island before it claims his sanity?